Opportunity Information: Apply for RFA NS 19 037
The Research Program Award (R35 Clinical Trial Optional), funding opportunity number RFA-NS-19-037, is a National Institute of Neurological Disorders and Stroke (NINDS) grant mechanism designed to shift support from narrowly defined, aim-by-aim projects to a broader, investigator-centered model. It is a reissue of RFA-NS-18-032 and is intended for established NINDS-funded investigators whose track records show they are positioned to make major, sustained contributions to neuroscience. Instead of funding a single, tightly scoped proposal that can constrain work to pre-specified milestones, this award supports an investigator's overall research program, giving them room to adapt, iterate, and pursue emerging opportunities as their science evolves.
A central feature of the R35 Research Program Award is longer-term support, providing funding for up to 8 years. The funding level is described as commensurate with the program director/principal investigator's recent NINDS support, meaning the award amount is generally calibrated to what the investigator has recently been funded by NINDS rather than being driven solely by a brand-new set of narrowly defined specific aims. In practice, the program is meant to create stability and continuity so that investigators can plan and execute longer-range research strategies, build teams, and sustain complex lines of inquiry that may not fit neatly into traditional short funding cycles.
The program is built around the idea that stable and flexible funding improves scientific ambition and efficiency. NINDS highlights several intended benefits: a more predictable funding environment to pursue longer-term goals; flexibility to redirect resources toward promising findings or unexpected breakthroughs without needing to rewrite an entire grant structure; less time spent writing repeated applications and managing multiple overlapping awards; and more time for investigators to mentor trainees and junior scientists. The overarching goal is to allow productive neuroscience investigators to take on higher-risk, higher-reward work, explore new directions, and extend prior discoveries in ways that might require more time or adaptability than a standard project grant provides.
All proposed research must fall squarely within the NINDS mission area, meaning it must be relevant to neurological disorders, stroke, and fundamental neuroscience within NINDS scope. The announcement explicitly notes that research outside the NINDS mission, or work that is traditionally supported by another NIH Institute or Center, will not be considered under this program. The "Clinical Trial Optional" designation indicates that clinical trials may be included if appropriate, but they are not required; applicants can propose either clinical trial or non-clinical trial research as long as it aligns with NINDS priorities and the investigator's overall program vision.
Eligibility is intentionally narrow and focused on investigators with an ongoing and sustained NINDS funding record. To apply, an investigator must currently hold at least one active NINDS R01 or an R01-equivalent award, where NINDS defines R01-equivalents for this purpose as R00, R01, R37, R56, DP1, or DP2. Beyond current funding, the investigator must also have had an active NINDS R01-equivalent award in each of the past five years, with the added condition that no more than one of those years may have been spent in a no-cost extension. This requirement is meant to ensure that applicants have demonstrated consistent, competitive support from NINDS and are likely to benefit from the program-style, long-horizon funding model.
From an administrative standpoint, the opportunity is offered by the U.S. Department of Health and Human Services through the National Institutes of Health, with activity in the health category and CFDA number 93.853. The eligible applicant organizations span a wide range, including public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), for-profit organizations other than small businesses, small businesses, and multiple levels of government and tribal entities, among others. Even though institutions can be varied, the practical gatekeeper is the investigator-level eligibility tied to sustained NINDS R01-equivalent support. The opportunity listing indicated an expected number of awards of about 30 and showed an award ceiling of 0, which typically means the ceiling is not specified in that summary field rather than implying zero dollars. The original closing date listed for this specific posting was July 30, 2019, and the creation date was May 29, 2019, which situates it as a time-limited solicitation for that cycle.
Overall, this R35 program is best understood as NINDS investing in people and programs rather than single projects. It is aimed at investigators already demonstrating strong performance under NINDS support and is structured to reduce churn, encourage bold neuroscience, and give laboratories the runway to pursue longer and potentially more transformative research trajectories while staying tightly aligned with NINDS mission priorities.Apply for RFA NS 19 037
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Research Program Award (R35 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853.
- This funding opportunity was created on May 29, 2019.
- Applicants must submit their applications by Jul 30, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 30 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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