Ruth L. Kirschstein National Research Service Award (NRSA) Individual Senior Fellowship (Parent F33) | PA 25 424

Opportunity Information: Apply for PA 25 424

The Ruth L. Kirschstein National Research Service Award (NRSA) Individual Senior Fellowship (Parent F33), funding opportunity number PA-25-424, is an NIH discretionary grant designed to support advanced, individualized research training for experienced scientists. It is aimed at established investigators who are at a point in their careers where additional, structured training would enable a significant pivot or expansion in their independent research program. In practical terms, this fellowship is meant for senior researchers who want to make a major change in research direction, enter a new scientific area, or add substantial new capabilities that will strengthen their long-term contributions in fields aligned with the missions of participating NIH Institutes and Centers.

The opportunity falls under the NIH research training fellowship framework and is categorized under the funding activity areas of education, environment, and health. The central purpose is workforce and capability development rather than simply funding a single research project; the proposed fellowship experience should clearly emphasize mentored training, acquisition of new skills, and a well-justified plan for how the applicant will emerge with an expanded or redirected research trajectory. Because this is a senior fellowship, the applicant is expected to already have a track record as an independent scientist, and the fellowship is used to support a deliberate period of advanced training to enable a meaningful next step in their career.

Eligible applicants span a wide range of organization types. Domestic public and state-controlled institutions of higher education, private institutions of higher education, and nonprofit organizations (both those with and without 501(c)(3) status) are eligible. For-profit organizations other than small businesses, as well as small businesses, are also listed as eligible applicants, along with an "other" category that can include additional organization types as defined by NIH policy. Notably, the opportunity explicitly includes certain additional eligible applicants beyond the typical list, including eligible agencies of the federal government and non-domestic (non-U.S.) entities, meaning foreign organizations may apply or otherwise be involved consistent with NIH rules for this mechanism. This can matter for senior scientists whose training plan requires a specific international setting, collaboration, population, or technique that is best obtained outside the United States.

The opportunity is associated with multiple CFDA numbers, reflecting participation across different NIH Institutes and Centers and their mission areas. The CFDA numbers listed are 93.113, 93.121, 93.233, 93.279, 93.310, 93.837, 93.838, 93.839, 93.840, 93.846, and 93.859. This breadth signals that the fellowship can support training that fits within a wide range of NIH-relevant biomedical, behavioral, clinical, and health-related research areas, so long as the proposed training aligns clearly with the priorities of at least one participating Institute or Center.

From an administrative standpoint, the opportunity was created on 2025-06-12 and lists an original closing date of 2028-05-07. The source data does not specify an award ceiling or the expected number of awards, which often means applicants should rely on NIH fellowship budget structures and the typical NRSA framework rather than expecting a single published maximum or a guaranteed volume of awards. Overall, this is a long-running parent announcement-style fellowship opportunity intended to remain open over multiple receipt cycles, supporting senior investigators who can justify that a defined period of mentored research training will lead to a substantial and credible evolution in their independent scientific career.

• The National Institutes of Health in the education, environment, health sector is offering a public funding opportunity titled "Ruth L. Kirschstein National Research Service Award (NRSA) Individual Senior Fellowship (Parent F33)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.233, 93.279, 93.310, 93.837, 93.838, 93.839, 93.840, 93.846, 93.859.
• This funding opportunity was created on 2025-06-12.
• Applicants must submit their applications by 2028-05-07.
• Eligible applicants include: Public and State controlled institutions of higher education, Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PA 25 424

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