Opportunity Information: Apply for PA 25 424
The Ruth L. Kirschstein National Research Service Award (NRSA) Individual Senior Fellowship (Parent F33), funding opportunity number PA-25-424, is an NIH discretionary grant designed to support advanced, individualized research training for experienced scientists. It is aimed at established investigators who are at a point in their careers where additional, structured training would enable a significant pivot or expansion in their independent research program. In practical terms, this fellowship is meant for senior researchers who want to make a major change in research direction, enter a new scientific area, or add substantial new capabilities that will strengthen their long-term contributions in fields aligned with the missions of participating NIH Institutes and Centers.
The opportunity falls under the NIH research training fellowship framework and is categorized under the funding activity areas of education, environment, and health. The central purpose is workforce and capability development rather than simply funding a single research project; the proposed fellowship experience should clearly emphasize mentored training, acquisition of new skills, and a well-justified plan for how the applicant will emerge with an expanded or redirected research trajectory. Because this is a senior fellowship, the applicant is expected to already have a track record as an independent scientist, and the fellowship is used to support a deliberate period of advanced training to enable a meaningful next step in their career.
Eligible applicants span a wide range of organization types. Domestic public and state-controlled institutions of higher education, private institutions of higher education, and nonprofit organizations (both those with and without 501(c)(3) status) are eligible. For-profit organizations other than small businesses, as well as small businesses, are also listed as eligible applicants, along with an "other" category that can include additional organization types as defined by NIH policy. Notably, the opportunity explicitly includes certain additional eligible applicants beyond the typical list, including eligible agencies of the federal government and non-domestic (non-U.S.) entities, meaning foreign organizations may apply or otherwise be involved consistent with NIH rules for this mechanism. This can matter for senior scientists whose training plan requires a specific international setting, collaboration, population, or technique that is best obtained outside the United States.
The opportunity is associated with multiple CFDA numbers, reflecting participation across different NIH Institutes and Centers and their mission areas. The CFDA numbers listed are 93.113, 93.121, 93.233, 93.279, 93.310, 93.837, 93.838, 93.839, 93.840, 93.846, and 93.859. This breadth signals that the fellowship can support training that fits within a wide range of NIH-relevant biomedical, behavioral, clinical, and health-related research areas, so long as the proposed training aligns clearly with the priorities of at least one participating Institute or Center.
From an administrative standpoint, the opportunity was created on 2025-06-12 and lists an original closing date of 2028-05-07. The source data does not specify an award ceiling or the expected number of awards, which often means applicants should rely on NIH fellowship budget structures and the typical NRSA framework rather than expecting a single published maximum or a guaranteed volume of awards. Overall, this is a long-running parent announcement-style fellowship opportunity intended to remain open over multiple receipt cycles, supporting senior investigators who can justify that a defined period of mentored research training will lead to a substantial and credible evolution in their independent scientific career.Apply for PA 25 424
- The National Institutes of Health in the education, environment, health sector is offering a public funding opportunity titled "Ruth L. Kirschstein National Research Service Award (NRSA) Individual Senior Fellowship (Parent F33)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.233, 93.279, 93.310, 93.837, 93.838, 93.839, 93.840, 93.846, 93.859.
- This funding opportunity was created on 2025-06-12.
- Applicants must submit their applications by 2028-05-07.
- Eligible applicants include: Public and State controlled institutions of higher education, Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: Ruth L. Kirschstein NRSA Individual Senior Fellowship (Parent F33) - PA-25-424
What is this funding opportunity?
The Ruth L. Kirschstein National Research Service Award (NRSA) Individual Senior Fellowship (Parent F33) is an NIH discretionary grant (funding opportunity number PA-25-424) that supports advanced, individualized research training for experienced scientists. The emphasis is on structured, mentored training that strengthens a senior investigator's capabilities and enables a meaningful shift or expansion in their independent research program.
Who is this fellowship designed for?
This fellowship is aimed at established investigators who already have a track record as independent scientists and are at a career point where additional, structured training would enable a significant pivot, entry into a new scientific area, or acquisition of substantial new capabilities.
What is the main goal of the F33 senior fellowship?
The central purpose is workforce and capability development rather than simply funding a single research project. The proposed fellowship experience is expected to focus on mentored training, gaining new skills, and presenting a well-justified plan for how the applicant will emerge with an expanded or redirected research trajectory.
Is this primarily a research project grant or a training fellowship?
Based on the description provided, this opportunity sits within the NIH research training fellowship framework. It is intended to support a deliberate period of advanced training, with the research experience serving as a vehicle for mentored skill development and career evolution.
What kinds of career changes does this fellowship support?
The fellowship is meant for senior researchers who want to make a major change in research direction, enter a new scientific area, or add substantial new capabilities that strengthen their long-term contributions in areas aligned with participating NIH Institutes and Centers.
What activity areas does NIH associate with this opportunity?
The opportunity is categorized under the funding activity areas of education, environment, and health, consistent with its role as a research training fellowship supporting the development of investigator capabilities.
Which organizations are eligible to apply?
Eligible applicant organization types include:
- Domestic public and state-controlled institutions of higher education
- Private institutions of higher education
- Nonprofit organizations (with or without 501(c)(3) status)
- For-profit organizations other than small businesses
- Small businesses
- Other organization types as allowed by NIH policy
Can federal government agencies apply?
Yes. The opportunity explicitly includes eligible agencies of the federal government among the additional eligible applicants.
Are non-U.S. (foreign) organizations eligible?
Yes. The opportunity explicitly includes non-domestic (non-U.S.) entities, meaning foreign organizations may apply or otherwise be involved consistent with NIH rules for this mechanism.
Why does foreign eligibility matter for a senior fellowship?
The listing notes that this can be important for senior scientists whose training plan requires a specific international setting, collaboration, population, or technique that is best obtained outside the United States, as long as it is consistent with NIH rules for the mechanism.
What NIH mission areas can this fellowship align with?
The fellowship can support training that fits within a wide range of NIH-relevant biomedical, behavioral, clinical, and health-related research areas, as long as the proposed training aligns clearly with the priorities of at least one participating NIH Institute or Center.
What CFDA numbers are associated with this opportunity?
The CFDA numbers listed for this opportunity are: 93.113, 93.121, 93.233, 93.279, 93.310, 93.837, 93.838, 93.839, 93.840, 93.846, and 93.859. The presence of multiple CFDA numbers reflects participation across different NIH Institutes and Centers and their mission areas.
When was this opportunity created?
The opportunity was created on 2025-06-12.
What is the original closing date listed for this opportunity?
The source information lists an original closing date of 2028-05-07.
Does the opportunity publish an award ceiling?
The source information does not specify an award ceiling. This often indicates that applicants should rely on NIH fellowship budget structures and the typical NRSA framework rather than expecting a single published maximum within the listing.
Does the opportunity specify how many awards NIH expects to make?
No. The source information does not specify the expected number of awards.
Is this a one-time competition or a long-running announcement?
The description characterizes this as a long-running parent announcement-style fellowship opportunity intended to remain open over multiple receipt cycles, rather than a single one-time competition.
What should a strong training plan emphasize for this senior fellowship?
Based on the description provided, the fellowship plan should clearly emphasize mentored training, acquisition of new skills, and a well-justified rationale for how the training period will enable a substantial and credible evolution of the applicant's independent scientific career.
How does NIH describe the applicant's expected career stage?
This is described as a senior fellowship for experienced scientists. The applicant is expected to already have a track record as an independent scientist, with the fellowship supporting a deliberate training period that enables a meaningful next step.
What is the funding opportunity number and mechanism name?
The funding opportunity number is PA-25-424, and the mechanism is the Ruth L. Kirschstein National Research Service Award (NRSA) Individual Senior Fellowship (Parent F33).
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