Opportunity Information: Apply for HT942524TERPIIRA

The Toxic Exposures Investigator-Initiated Research Award (FY24 TERP IIRA) is a competitive research grant from the Department of the Army, administered through the U.S. Army Medical Research Acquisition Activity (USAMRAA). It is designed to fund investigator-driven studies that meaningfully advance scientific understanding and/or improve patient care for diseases and health conditions linked to military-related toxic exposures. The central theme is impact: proposals should be positioned to make an important contribution to the evidence base, clinical knowledge, or future care pathways for exposure-associated outcomes affecting military populations.

The opportunity is broad in the kinds of science it will support, spanning the full research pipeline. Projects can be basic laboratory studies that uncover mechanisms of disease, translational efforts that move discoveries toward practical use, and preclinical research using animal models. The program also explicitly allows human subjects research, which can include observational or interventional components depending on the project design and the rules applicable to the specific study. In addition, applicants may propose correlative or ancillary studies tied to an existing clinical trial, which is often a practical way to generate high-value biological or exposure-response insights while leveraging an already-established trial infrastructure.

A notable feature is the allowance for New Approach Methodologies (NAMs). In this context, NAMs typically refer to modern alternatives and complements to traditional testing and modeling approaches, such as advanced in vitro systems (including organoids or microphysiological systems), computational and in silico modeling, high-content screening, and other innovative platforms that can improve relevance, efficiency, or ethical considerations in exposure-related research. The inclusion of NAMs signals that the program is open to contemporary tools that can accelerate discovery or refine how toxic exposure effects are characterized.

Administratively, this is a discretionary grant opportunity in the Science and Technology and other Research and Development category (CFDA 12.420). The funding opportunity number is HT942524TERPIIRA, and the opportunity title is Toxic Exposures Investigator-Initiated Research Award. Eligibility is listed as unrestricted, meaning there are no special applicant-type limitations stated in the summary data provided (for example, it is not limited only to universities or only to nonprofits in the abstracted listing). The posted original application closing date is November 7, 2024. The program anticipates making about four awards. The award ceiling is not specified in the provided source details, so applicants would need to consult the full announcement or program guidelines for maximum budget limits, allowable costs, performance period, and any cost-sharing expectations if they exist.

Overall, the TERP IIRA is best understood as a flexible, impact-focused mechanism for researchers proposing rigorous, well-justified studies that connect military-relevant toxic exposures to measurable health outcomes, biological mechanisms, diagnostics, risk stratification, prevention strategies, or care improvements. The program structure encourages both foundational discovery and nearer-term translational work, including studies that can directly inform clinical decision-making or improve understanding of exposure-associated disease processes in military and veteran populations.

  • The Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "Toxic Exposures Investigator-Initiated Research Award" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
  • This funding opportunity was created on 2024-06-26.
  • Applicants must submit their applications by 2024-11-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The number of recipients for this funding is limited to 4 candidate(s).
  • Eligible applicants include: Unrestricted.
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