Opportunity Information: Apply for RFA OD 21 003
This funding opportunity, titled "Secondary Analyses of Existing Datasets of Tobacco Use and Health (R21 Clinical Trial Not Allowed)" (RFA-OD-21-003), is a National Institutes of Health (NIH) discretionary grant that supports short, innovative research projects using an R21 mechanism. The core aim is to fund creative secondary analyses of already-existing, publicly available datasets to advance research connected to tobacco use and health, specifically in areas that align with the regulatory science and public health priorities of the Food and Drug Administration (FDA) Center for Tobacco Products (CTP). Rather than generating new data through primary data collection or running a clinical trial, applicants are expected to use existing data to test new ideas, answer emerging questions, or build new analytical approaches that could meaningfully influence biomedical or biobehavioral research related to tobacco products and their impacts.
A central emphasis of the announcement is on using nationally representative U.S. datasets, including both cross-sectional and longitudinal sources. Cross-sectional datasets can help researchers characterize patterns, disparities, and associations at a given time point, while longitudinal datasets can support analyses of trajectories, transitions in tobacco use behaviors, and longer-term health outcomes. Although the FOA states that other publicly available datasets may be acceptable if they fit the proposed analyses, it clearly signals that applications leveraging nationally representative analyses will be prioritized. In practice, this means proposals that can generalize findings to the U.S. population and speak to broad public health and regulatory questions are especially encouraged.
The FOA is designed for innovative work, not just routine reanalysis. It invites projects that pursue novel scientific ideas or that develop new models, systems, tools, methods, or technologies. That could include, for example, new statistical or computational methods for analyzing tobacco use patterns, improved modeling of initiation and cessation behaviors, innovative ways to harmonize measures across surveys, or tools that help predict health outcomes or population-level impacts tied to tobacco products. The emphasis on "potential for significant impact" reflects the expectation that, even though the projects rely on existing datasets, they should produce insights or capabilities that move the field forward in a substantial way, particularly in domains relevant to FDA CTP.
The opportunity is classified as "Clinical Trial Not Allowed," which means the supported work must not involve prospective assignment of participants to interventions or conditions to assess health-related outcomes. Instead, the allowable activities are secondary analyses of existing data, likely including observational analyses, modeling, methodological development, and similar work that does not introduce a clinical trial design. Applicants should be prepared to clearly frame their research as secondary data analysis and ensure the proposal remains within the non-clinical-trial scope.
In terms of award parameters and competitiveness, the listed award ceiling is $200,000, and the FOA anticipated making about 5 awards. This suggests a relatively selective program with modest budgets typical of exploratory/developmental R21 projects. The program ran with an original closing date of March 8, 2023, and the FOA was created on March 10, 2021, under CFDA number 93.077 within the U.S. Department of Health and Human Services, NIH.
Eligibility is broad and includes many organization types across the public, nonprofit, academic, and private sectors. Eligible applicants include state, county, and local governments; special district governments; independent school districts; public and private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (excluding institutions of higher education in those categories); for-profit organizations (other than small businesses); small businesses; and other entities as described in the FOA's additional eligibility guidance. This breadth makes the opportunity accessible to a wide range of research organizations, provided they can demonstrate the expertise and capacity to conduct advanced analyses of large-scale publicly available datasets and produce outputs relevant to tobacco-related regulatory science.
Overall, the grant is best understood as support for high-impact, creativity-driven research that extracts new value from existing nationally representative U.S. tobacco and health datasets. The ideal project would be clearly aligned with FDA CTP-relevant questions, methodologically strong, and framed around innovation, whether through new scientific insights, new analytic frameworks, or practical tools and methods that other researchers and stakeholders could build on.Apply for RFA OD 21 003
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Secondary Analyses of Existing Datasets of Tobacco Use and Health (R21 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.077.
- This funding opportunity was created on Mar 10, 2021.
- Applicants must submit their applications by Mar 08, 2023. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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