Opportunity Information: Apply for PAR 23 053
The National Institutes of Health (NIH) funding opportunity titled "Research Infrastructure Development for Interdisciplinary Aging Studies (R61/R33 - Clinical Trial Optional)" (Funding Opportunity Number PAR-23-053) supports efforts to build new, sustainable research infrastructure that can accelerate progress in aging science, especially in areas where solving the problem depends on bringing together multiple disciplines, partners, or sectors. The emphasis is not simply on running a single research study, but on creating the tools, platforms, networks, shared resources, or coordination structures that make a broader portfolio of interdisciplinary aging research possible and more effective over time. Clinical trials are optional under this announcement, meaning applicants may propose projects that include clinical trial elements if they are appropriate to the infrastructure being developed, but a clinical trial is not required.
This opportunity uses the NIH Phased Innovation Award mechanism (R61/R33), which is designed for projects that need an initial, clearly defined development period before scaling up. The first phase, the R61, can provide up to two years of support to complete early-stage developmental milestones. In practical terms, this phase is meant for planning, piloting, building, testing feasibility, and demonstrating that the proposed infrastructure can function as intended. If the R61 phase meets its predetermined milestones, the project can transition into the second phase, the R33, which can provide up to three additional years to expand, operationalize, and more broadly implement the infrastructure. Across both phases, the expectation is that the end product is sustainable, meaning it can continue to support interdisciplinary aging research beyond the award period through institutional commitment, cost-recovery models, partnerships, or other long-term maintenance strategies.
The core purpose is to advance the science of aging by enabling projects that address key interdisciplinary research questions. While the announcement summary does not list specific scientific topics, it signals that NIH is looking for infrastructure that meaningfully strengthens research capacity at the intersections of fields. That could include, for example, shared data resources and harmonization methods across cohorts, research networks that connect clinical, behavioral, social, and biological aging investigators, platforms that enable multi-site collaboration, community-engaged research infrastructure for older adult populations, specialized cores that provide measurement or analytic capabilities, or other enabling structures that help teams study aging in more integrated ways. The unifying theme is that the infrastructure should be novel, justified by a clear need in the interdisciplinary aging space, and designed to support multiple projects or users rather than only a single investigator's aims.
Eligibility is broad and includes many types of U.S.-based organizations and government entities. Eligible applicants include state, county, city, township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; and tribal organizations that are not federally recognized. The opportunity is also open to public housing authorities/Indian housing authorities, nonprofits with or without 501(c)(3) status (other than institutions of higher education), and for-profit organizations (other than small businesses) as well as small businesses. NIH also explicitly highlights additional eligible applicant categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions. These eligibility statements underscore NIH interest in a wide range of institutional settings, including those that serve populations often underrepresented in research and those positioned to build community-facing or regionally coordinated infrastructure.
At the same time, there are important restrictions related to foreign participation. Non-domestic (non-U.S.) entities (foreign organizations and foreign institutions) are not eligible to apply as the primary applicant organization, and non-domestic components of U.S. organizations are also not eligible to apply. However, foreign components are allowed as defined by the NIH Grants Policy Statement, which means a U.S. applicant may include certain foreign elements in the project when scientifically justified and compliant with NIH policy, even though the main applicant organization must be domestic.
From an administrative perspective, this is a discretionary grant in the health funding category, administered by NIH, with CFDA numbers 93.313 and 93.866. The original closing date listed is 2025-12-02. The award ceiling shown in the source data is $500,000, which signals the upper limit reflected in the summary provided (applicants would still need to align budgets with NIH rules, the FOA's detailed budget guidance, and the scope of proposed milestones across the R61 and R33 phases). Overall, the opportunity is aimed at teams that can define a concrete infrastructure gap in interdisciplinary aging research, propose a credible phased development and scale-up plan, and deliver a resource that remains useful and viable well beyond the funding period.Apply for PAR 23 053
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Research Infrastructure Development for Interdisciplinary Aging Studies (R61/R33 - Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.313, 93.866.
- This funding opportunity was created on 2022-11-21.
- Applicants must submit their applications by 2025-12-02. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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