Opportunity Information: Apply for DE FOA 0003063
The Department of Energy (DOE), Office of Science, is seeking grant applications under Funding Opportunity Announcement (FOA) DE-FOA-0003063 titled "Research, Development, and Training in Isotope Production." This opportunity sits within the DOE Office of Science program for Isotope Research and Development and Production, commonly called the DOE Isotope Program (DOE IP). The main goal is to fund research and development projects that address high-priority needs in the U.S. isotope supply chain, specifically by increasing the availability of radioactive isotopes and enriched stable isotopes that are currently in short supply. The FOA emphasizes practical, high-impact R&D that can strengthen production capability, improve processes, and ultimately reduce supply risks for isotopes needed across fields like medicine, national security, industry, and scientific research.
A central requirement is that proposed R&D must be complementary to existing capabilities and current federally funded efforts, not duplicative. In other words, applicants should show that their work fills a real gap: generating new data, developing new technology, improving production methods, or advancing processing and purification approaches in ways that are not already being done elsewhere with federal support. Competitive proposals will typically make a clear case for why the isotope shortage matters, what technical barrier is limiting production or availability, and how the project will produce usable results that can be taken up by production programs or facilities.
The FOA also strongly encourages projects that incorporate workforce development, training, and diversity-building elements. DOE is looking for applications that help prepare the next generation of people who can do isotope production work, including the specialized knowledge and hands-on skills associated with producing, processing, and purifying radioactive isotopes and enriched stable isotopes. This can include structured training experiences for students and early-career researchers, curriculum or module development tied to real isotope production challenges, mentorship plans, and pathways that broaden participation in this highly specialized workforce. The training component is framed as a meaningful part of the overall project rather than an afterthought, with an emphasis on building lasting capacity in the field.
From an administrative standpoint, this is a discretionary grant program in the Science and Technology and other Research and Development category (CFDA 81.049). Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, and nonprofit organizations, including both 501(c)(3) and non-501(c)(3) nonprofits that are not higher education institutions. The FOA was created on May 5, 2023, with an original application closing date of July 5, 2023. DOE anticipated making about 8 awards, with an award ceiling of up to $1,500,000 per award. Overall, the opportunity is aimed at targeted R&D and associated training that can measurably improve isotope availability while also strengthening the talent pipeline needed to sustain and expand U.S. isotope production capabilities.Apply for DE FOA 0003063
- The Department of Energy - Office of Science, Office of Science in the science and technology and other research and development sector is offering a public funding opportunity titled "Research, Development, and Training in Isotope Production" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 81.049.
- This funding opportunity was created on May 05, 2023.
- Applicants must submit their applications by Jul 05, 2023. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,500,000.00 in funding.
- The number of recipients for this funding is limited to 8 candidate(s).
- Eligible applicants include: Public and State controlled institutions of higher education, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education.
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Frequently Asked Questions (FAQs)
What is the funding opportunity being offered?
The Department of Energy (DOE), Office of Science, is seeking grant applications under Funding Opportunity Announcement (FOA) DE-FOA-0003063 titled "Research, Development, and Training in Isotope Production."
Which DOE program is this FOA associated with?
This FOA sits within the DOE Office of Science program for Isotope Research and Development and Production, commonly known as the DOE Isotope Program (DOE IP).
What is the main purpose of this FOA?
The main goal is to fund research and development projects that address high-priority needs in the U.S. isotope supply chain by increasing the availability of radioactive isotopes and enriched stable isotopes that are currently in short supply.
What kinds of isotopes are the focus of the FOA?
The FOA specifically highlights radioactive isotopes and enriched stable isotopes that are in short supply and where improved production capability or processes could reduce supply risks.
Why is DOE funding this work?
DOE is aiming to reduce supply risks and strengthen U.S. isotope availability for uses across medicine, national security, industry, and scientific research.
What types of projects are DOE looking for?
The FOA emphasizes practical, high-impact R&D that can strengthen production capability, improve processes, and advance processing and purification approaches in ways that result in usable outcomes for isotope production programs or facilities.
What does "high-impact" or "practical" R&D mean in this FOA?
Based on the FOA description, competitive work is expected to address real constraints in isotope availability (for example, a technical barrier limiting production or supply) and produce results that can be taken up by production efforts to measurably improve availability.
Does the FOA require that projects address a specific shortage or supply-chain need?
Yes. The FOA is aimed at high-priority needs in the U.S. isotope supply chain, particularly where isotopes are currently in short supply. Competitive proposals typically make a clear case for why a shortage matters and what barrier is limiting availability.
What does DOE mean by "complementary" rather than "duplicative" research?
Proposed R&D must be complementary to existing capabilities and current federally funded efforts, not duplicative. Applicants are expected to show their work fills a real gap, such as generating new data, developing new technology, improving production methods, or advancing processing/purification approaches that are not already being pursued elsewhere with federal support.
How can an applicant demonstrate their work is not duplicative?
The FOA language indicates applicants should explain what existing capabilities and federally funded efforts are already in place and clearly identify the gap their project fills, emphasizing what is new (data, technology, process improvement, or processing/purification advancement) and why it is not already covered by other federal support.
Is workforce development or training part of this FOA?
Yes. The FOA strongly encourages projects that incorporate workforce development, training, and diversity-building elements.
What kinds of training activities are encouraged?
Examples described include structured training experiences for students and early-career researchers, curriculum or module development tied to real isotope production challenges, mentorship plans, and pathways that broaden participation in isotope production work.
How important is the training component to DOE?
The training component is framed as a meaningful part of the overall project rather than an afterthought, with an emphasis on building lasting capacity in the isotope production workforce.
What specialized skills or knowledge is DOE trying to build through this FOA?
DOE highlights the specialized knowledge and hands-on skills associated with producing, processing, and purifying radioactive isotopes and enriched stable isotopes.
Who is eligible to apply?
Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, and nonprofit organizations (including both 501(c)(3) and non-501(c)(3) nonprofits that are not higher education institutions).
Are for-profit companies listed as eligible applicants in the provided information?
No. The provided eligibility list includes higher education institutions and nonprofit organizations, but does not mention for-profit entities.
What is the program type and category for this grant?
This is described as a discretionary grant program in the Science and Technology and other Research and Development category.
What is the CFDA number for this opportunity?
The opportunity is listed under CFDA 81.049.
When was the FOA created?
The FOA was created on May 5, 2023.
What was the original application closing date?
The original application closing date was July 5, 2023.
How many awards did DOE anticipate making?
DOE anticipated making about 8 awards.
What is the maximum award size (award ceiling)?
The award ceiling is up to $1,500,000 per award.
What is the overall goal of the funded projects?
The overall aim is targeted R&D (with associated training) that can measurably improve isotope availability while also strengthening the talent pipeline needed to sustain and expand U.S. isotope production capabilities.
What fields or sectors benefit from the isotopes targeted by this FOA?
The FOA description notes isotopes needed across medicine, national security, industry, and scientific research.
What makes a proposal "competitive" according to the description provided?
Competitive proposals will typically: (1) make a clear case for why a specific isotope shortage matters, (2) identify the technical barrier limiting production or availability, (3) describe how the project addresses that barrier with practical, high-impact R&D, (4) show the work complements (and does not duplicate) existing federally funded efforts, and (5) produce usable results that can be taken up by production programs or facilities. Projects are also strongly encouraged to include meaningful workforce development and training elements.
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