NIAID Investigator Initiated Program Project Applications (P01 Clinical Trial Not Allowed) | PAR 20 072

Opportunity Information: Apply for PAR 20 072

The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), is soliciting investigator-initiated Program Project Grant (P01) applications under funding opportunity PAR-20-072. This is a discretionary grant opportunity in the health funding activity category (CFDA 93.855). The central purpose is to support large, multi-project research programs that tackle important questions aligned with the NIAID mission, with an emphasis on coordinated, synergistic science rather than a collection of unrelated studies. Clinical trials are not allowed under this announcement, so the supported work should be basic, mechanistic, preclinical, or other non-clinical-trial research, potentially including translational efforts that do not meet the NIH definition of a clinical trial.

The scientific scope is broad but focused on infectious diseases, immunology, and allergy. Proposed programs may address the biology and pathogenesis of microbes and the host response to those microbes, explicitly including HIV. NIAID is also interested in research on how the immune system develops and functions under normal conditions, and how immune dysfunction contributes to diseases such as autoimmunity, immunodeficiency, allergy, asthma, and transplant rejection. In addition, the FOA encourages translational research aimed at developing vaccines, therapeutics, and diagnostics to prevent or treat infectious, immune-mediated, and allergic diseases, as long as the work stays within the non-clinical-trial boundary set by the announcement.

A key structural requirement of this P01 mechanism is that each application must include at least two related research projects that share a common central theme, focus, and/or overall objective. In practice, this means the application should be built around a unifying scientific question or goal, with projects designed to complement one another and generate added value through collaboration, shared methods, shared resources, and coordinated leadership. A competitive P01 typically demonstrates that the combined program will achieve more than the same projects pursued independently, for example by integrating expertise across disciplines, sharing key cores or resources, or using findings from one project to drive experiments in another.

Eligibility is broad across U.S.-based organizations and governmental entities. Eligible applicants include state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; certain non-federally recognized tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (as long as they are not institutions of higher education when applying under those nonprofit categories); for-profit organizations other than small businesses; and small businesses. The FOA also highlights additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal agencies, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions.

Foreign eligibility is restricted in a way that often matters for collaborations. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply as the applicant organization, and non-domestic components of U.S. organizations are also not eligible to apply. However, foreign components are allowed as defined in the NIH Grants Policy Statement, meaning a U.S. applicant may include certain foreign elements within the project when justified and when compliant with NIH policy, even though a foreign institution cannot be the primary applicant.

The opportunity was created on 2019-12-09, and the listed original closing date in the provided source information is 2022-09-07. The award ceiling and expected number of awards are not specified in the source data you provided, which usually means applicants should rely on the FOA text and NIH policies to understand budget expectations, typical P01 scale, and any institute-specific limits or guidance. Overall, this FOA is best suited to teams that can propose a cohesive, multi-project research program tightly aligned with NIAID priorities in infectious disease and immunology, with clearly articulated synergy across at least two interrelated projects and no clinical trial activities.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "NIAID Investigator Initiated Program Project Applications (P01 Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855.
• This funding opportunity was created on 2019-12-09.
• Applicants must submit their applications by 2022-09-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

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