Opportunity Information: Apply for RFA AG 24 030
The Consortium for Economic Research on AD/ADRD Prevention, Treatment, and Care Coordinating Center (U54 Clinical Trial Optional) is a National Institutes of Health (NIH), National Institute on Aging (NIA) funding opportunity that supports the creation of a U54 Specialized Center operating as a cooperative agreement. The overall purpose is to strengthen and accelerate economic research related to Alzheimer's disease (AD) and AD-related dementias (ADRD), with a particular emphasis on how prevention, treatment, and care approaches are developed, adopted, paid for, and delivered in real-world settings. Rather than funding a single standalone study, the NOFO is designed to build and coordinate a consortium of multiple research projects and investigators, aligning their work to produce a more cohesive body of evidence that can inform policy and practice.
A central theme of the opportunity is understanding the economics behind the full pipeline of dementia-related innovations and services. The funded Center is expected to support research examining the development and diffusion of treatment and care innovations, meaning it looks at what drives new interventions or care approaches to spread (or fail to spread) across health systems and communities. It also prioritizes studies on payment and treatment models for dementia care, which can include how reimbursement structures, insurance design, incentives, and care delivery arrangements shape what patients and caregivers can access and what providers are able to offer. Another focus is care quality and access for people living with dementia (PLWD) and their caregivers, reflecting the reality that dementia care often depends on both formal medical services and informal caregiving supports, and that gaps in access or quality can have major financial and health consequences. The NOFO also highlights economic factors influencing disease progression, signaling interest in how socioeconomic conditions, resource availability, and related structural factors may affect outcomes over time. Collectively, these topic areas are tied to specific NIA AD/ADRD research implementation milestones (referenced as 1.P, 13.P, 13.M, and 13.N from a related NIA milestone framework), indicating that the Center should contribute to targeted, measurable progress in the AD/ADRD research agenda.
The Coordinating Center role goes beyond simply managing grants. The Center is expected to actively foster collaboration and synergy across consortium member projects, helping align methods, measures, and research questions where useful so that findings can be compared or integrated. It is also expected to initiate new research projects, meaning it should have the capacity to identify emerging needs or evidence gaps and launch additional work as the field evolves. Another explicit goal is to expand the network of researchers studying the economics of AD/ADRD, which implies workforce and community-building activities such as convenings, cross-disciplinary partnerships, and opportunities that bring new investigators or new disciplines into dementia economics research. Finally, the Center must disseminate findings to key stakeholders to support policymaking. In practice, this points toward making results usable by decision-makers such as federal and state agencies, health systems, payers, community organizations, and advocacy groups, and translating technical economic evidence into clear implications for programs, financing, and care delivery.
From an administrative standpoint, this is a discretionary funding opportunity using a cooperative agreement mechanism, which typically means NIH/NIA will have substantial involvement in oversight and collaboration compared to a standard research project grant. The activity category is health, and the associated CFDA number listed is 93.866. The opportunity is identified as RFA-AG-24-030, titled exactly as provided, and it was created on 2023-08-28 with an original closing date of 2023-11-30. The listed award ceiling is 2,750,000, and expected awards are not clearly specified in the provided source (the field appears blank), so applicants would need to consult the full NOFO for the anticipated number of awards and budget structure expectations.
Eligibility is broad across many U.S.-based organization types, reflecting an intent to draw participation from academic, nonprofit, government, and private-sector institutions with relevant expertise. Eligible applicants include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and certain tribal organizations; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories as stated); for-profit organizations other than small businesses; and small businesses. The NOFO also explicitly calls out additional eligible applicant categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISI), as well as faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions. At the same time, non-domestic (non-U.S.) entities and non-domestic components of U.S. organizations are not eligible to apply, although foreign components (as defined in NIH policy) are allowed, which typically means certain discrete project elements may occur outside the U.S. under a U.S. applicant organization when appropriately justified and compliant with NIH rules.
In plain terms, the grant is meant to build a hub that coordinates a portfolio of economic research on dementia prevention, treatment, and care, creates a stronger national research community around dementia economics, and produces policy-relevant evidence on how care and treatments are financed, accessed, delivered, and scaled for people living with dementia and the people who care for them.Apply for RFA AG 24 030
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Consortium for Economic Research on AD/ADRD Prevention, Treatment, and Care Coordinating Center (U54 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
- This funding opportunity was created on 2023-08-28.
- Applicants must submit their applications by 2023-11-30. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $2,750,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
1. What is this funding opportunity?
This is an NIH/NIA funding opportunity to establish the "Consortium for Economic Research on AD/ADRD Prevention, Treatment, and Care Coordinating Center (U54 Clinical Trial Optional)." It supports a U54 Specialized Center that operates as a cooperative agreement.
2. What is the main purpose of the Coordinating Center?
The purpose is to strengthen and accelerate economic research related to Alzheimer's disease (AD) and AD-related dementias (ADRD), especially research focused on how prevention, treatment, and care approaches are developed, adopted, paid for, and delivered in real-world settings.
3. Is this intended to fund one standalone research study?
No. The opportunity is designed to build and coordinate a consortium of multiple research projects and investigators, aligning their work to create a more cohesive body of evidence that can inform policy and practice.
4. Which NIH Institute is sponsoring this opportunity?
The sponsoring Institute is the National Institutes of Health (NIH), National Institute on Aging (NIA).
5. What is the funding mechanism and what does it imply?
The mechanism is a cooperative agreement (U54). A cooperative agreement typically means NIH/NIA will have substantial involvement in oversight and collaboration compared to a standard research project grant.
6. What does "U54 Clinical Trial Optional" mean in this context?
The opportunity is labeled "Clinical Trial Optional," indicating that clinical trials are not required for all projects under the Center. (Specific expectations would be detailed in the full NOFO.)
7. What research areas or themes does this Center emphasize?
The Center emphasizes the economics behind the full pipeline of dementia-related innovations and services, including prevention, treatment, and care approaches in real-world settings.
8. What does the NOFO mean by studying the "development and diffusion" of treatment and care innovations?
It refers to examining what drives new interventions or care approaches to spread (or fail to spread) across health systems and communities.
9. Are payment and reimbursement topics within scope?
Yes. The NOFO prioritizes studies on payment and treatment models for dementia care, including how reimbursement structures, insurance design, incentives, and care delivery arrangements shape access for patients and caregivers and what providers can offer.
10. Does the opportunity cover care quality and access for people living with dementia and caregivers?
Yes. A stated focus is care quality and access for people living with dementia (PLWD) and their caregivers, recognizing the role of both formal medical services and informal caregiving supports.
11. Are socioeconomic and structural factors related to disease progression part of the scope?
Yes. The NOFO highlights economic factors influencing disease progression, including how socioeconomic conditions, resource availability, and related structural factors may affect outcomes over time.
12. How does this opportunity connect to NIA milestones?
The topic areas are tied to NIA AD/ADRD research implementation milestones referenced as 1.P, 13.P, 13.M, and 13.N, indicating the Center is expected to contribute to targeted, measurable progress in the AD/ADRD research agenda.
13. What are the Coordinating Center's collaboration responsibilities?
The Center is expected to foster collaboration and synergy across consortium member projects, including aligning methods, measures, and research questions where useful so findings can be compared or integrated.
14. Is the Center expected to initiate new research projects over time?
Yes. The Center is expected to have the capacity to identify emerging needs or evidence gaps and launch additional work as the field evolves.
15. Does the opportunity include network-building or workforce development expectations?
Yes. An explicit goal is to expand the network of researchers studying the economics of AD/ADRD, implying community-building activities such as convenings, cross-disciplinary partnerships, and opportunities that bring in new investigators or disciplines.
16. What dissemination expectations are described?
The Center must disseminate findings to key stakeholders to support policymaking, translating economic evidence into clear implications for programs, financing, and care delivery.
17. Who are examples of the intended stakeholders for dissemination?
The description points to stakeholders such as federal and state agencies, health systems, payers, community organizations, and advocacy groups.
18. What is the activity category and CFDA number listed?
The activity category is health, and the CFDA number listed is 93.866.
19. What is the opportunity number and official title?
The opportunity is identified as RFA-AG-24-030, titled "The Consortium for Economic Research on AD/ADRD Prevention, Treatment, and Care Coordinating Center (U54 Clinical Trial Optional)."
20. When was the opportunity created and what was the original closing date?
It was created on 2023-08-28, with an original closing date of 2023-11-30.
21. What is the award ceiling for this opportunity?
The listed award ceiling is 2,750,000.
22. How many awards are expected?
The expected number of awards is not clearly specified in the provided information (the field appears blank). Applicants would need to consult the full NOFO for anticipated award counts and budget structure expectations.
23. Who is eligible to apply?
Eligibility is broad and includes many U.S.-based organization types across academia, nonprofit, government, and private-sector institutions with relevant expertise.
24. Are state, county, or local governments eligible?
Yes. State, county, and local governments are listed as eligible applicants, including special district governments and independent school districts.
25. Are colleges and universities eligible?
Yes. Public and state-controlled institutions of higher education and private institutions of higher education are eligible.
26. Are tribal governments and tribal organizations eligible?
Yes. Federally recognized Native American tribal governments and certain tribal organizations are listed as eligible.
27. Are public housing authorities eligible?
Yes. Public housing authorities/Indian housing authorities are listed as eligible.
28. Are nonprofit organizations eligible?
Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status are listed as eligible, with the provided information noting exclusions "as stated" regarding institutions of higher education in those nonprofit categories.
29. Are for-profit organizations eligible?
Yes. For-profit organizations other than small businesses are eligible, and small businesses are also listed as eligible.
30. Are certain institution types explicitly encouraged or called out as eligible?
Yes. The NOFO explicitly calls out eligibility categories including HBCUs, Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and AANAPISIs.
31. Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly listed among eligible applicant categories.
32. Are federal agencies eligible?
Yes. Eligible federal agencies are included in the listed eligible applicant categories.
33. Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are listed as eligible.
34. Are non-U.S. (non-domestic) entities eligible to apply?
No. Non-domestic (non-U.S.) entities and non-domestic components of U.S. organizations are not eligible to apply.
35. Are foreign components allowed at all?
Yes. Foreign components (as defined in NIH policy) are allowed, meaning discrete project elements may occur outside the U.S. under a U.S. applicant organization when justified and compliant with NIH rules.
36. In plain terms, what is NIH/NIA trying to build with this grant?
The grant is meant to build a hub that coordinates a portfolio of economic research on dementia prevention, treatment, and care; strengthens the national research community around dementia economics; and produces policy-relevant evidence on how care and treatments are financed, accessed, delivered, and scaled for people living with dementia and their caregivers.
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